Evaluation of semiquantitative analysis mode in ICP-MS

Semiquantitative analysis mode in inductively coupled plasma mass spectrometry (ICP-MS) has been popularly used for fast screening purposes. Although the benefit of it has been studied by many researchers, its performance of application in real-world routine analyses has not been reported.

In this study, we evaluated the reliability of semiquantitative analysis mode through inter-laboratory comparison using two different ICP-MS systems with one multi-element calibration standard. The suitability of semiquantitative analysis mode in routine analysis laboratory was demonstrated by evaluating its application in different laboratories and in real production laboratory practices. Twenty one elements were measured, namely, Be, B, Al, Ti, V, Cr, Mn, Co, Ni, Cu, Zn, As, Sr, Mo, Ag, Cd, Sn, Sb, Ba, Tl, and Pb in various fresh water reference samples. Good results concerning accuracy (relative percentage error within 10%) and reproducibility (relative standard deviation lower than 5%) were obtained in more than 90% analyzed samples at concentrations equal to or greater than 10 times the detection limit (DL). Semiquantitative analysis mode also enabled the determination of elements that are not present in the calibration standard. The results demonstrated the potential of semiquantitative analysis mode as a reliable approach in routine laboratory determination of simple matrices, where high throughput and cost-effectiveness are desired, as well as in emergency situations where speed of analysis is critical and quite often limited sample information is available.     

Structural Damage Identification Using an Adaptive Multi-stage Optimization Method Based on a Modified Particle Swarm Algorithm

An adaptive multi-stage optimization method utilizing a modified particle swarm optimization (MPSO) is proposed here to identify the multiple damage cases of structural systems. First the structural damage problem is defined as a standard optimization problem. An efficient objective function considering the first few natural frequencies of a structure, before and after damage, is utilized for optimization. A modified particle swarm optimization (MPSO) dealing with real values of damage variables is introduced to solve the optimization problem. In order to assess the performance of the proposed method, some illustrative examples with and without considering the measurement noise are tested. Numerical results demonstrate the high accuracy of the method proposed for determining the site and severity of multiple damage cases in the structural systems.     

Method development and validation for trifluoroacetic acid determination by capillary electrophoresis in combination with capacitively coupled contactless conductivity detection (CE-C4D)

A method was developed to determine traces of trifluoroacetic acid as impurity in synthetic or semi-synthetic drugs as antibiotics, macropeptides, etc. Capillary electrophoresis in combination with capacitively coupled contactless conductivity detection (CE-C⁴D) was used due to lack of UV absorbance property of trifluoroacetic acid (TFA). The optimized method took less than 1 min with good linearity (R² = 0.9995) for trifluoroacetic acid concentration from 2 to 100 ppm. It also has a good repeatability expressed by the relative standard deviation (% RSD) which is 1.2 and 2.1% for intraday and interday precision, respectively, at 50 ppm TFA, and good sensitivity with 0.34 ppm, 1.2 ppm LOD and LOQ, respectively. In addition, the content of TFA in synthetic drug, was determined using the validated method which gave good linearity (R² = 0.9996) for trifluoroacetic acid spiked into drug in a concentration range of 2-80 ppm, with good intraday repeatability of 2.0%.The analysis is performed in a background electrolyte composed of 20 mM morpholinoethane-sulfonic acid (Mes) and 20 mM l-histidine (l-His) pH 6.1. Cetyltrimethylammonium bromide (CTAB) was added as flow modifier in a concentration (0.2 mM) lower than the critical micellar concentration. Ammonium formate 6 ppm was used as internal standard. The applied voltage was 30 kV in reverse polarity. A fused silica capillary with 75 μm internal diameter and total length 47 cm (31 cm to C⁴D detector and 37 cm to DAD detector) was used.     

Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues

An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K(2)CO(3) in toluene-EtOH-H(2)O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction.     

Bose Condensates in Interaction with Excitations: A Kinetic Model

This paper deals with mathematical questions for Bose gases below the temperature T _BEC where Bose-Einstein condensation sets in. The model considered is of two-component type, consisting of a kinetic equation for the distribution function of a gas of (quasi-)particles interacting with a Bose condensate, which is described by a Gross-Pitaevskii equation. Existence results and moment estimates are proved in the space-homogeneous, isotropic case.     

Spray characteristics of a gasoline direct injector injector with short durations of injection

The sprays into atmosphere from a GDI injector were visualised and the velocity and droplet characteristics measured at an injection pressure of 50 bar and at different injection durations, with emphasis on short injection periods. The images show that the initial and closing delay times were 0.225 and 0.2 ms, respectively, and that the cone angle increased with injection duration to a constant value of 62° at 0.5 ms. They also revealed large droplets ahead of the main spray with its smaller droplets. An injection duration of 0.15 ms led to fuel leaving the injector with little atomisation, but a 30% increase led to the formation of the cone, which was present for times greater than 0.5 ms. The poor atomisation associated with short injection durations and the initial phase of longer injections, was due to low swirl velocities. The droplet velocities were higher in the initial phase of injection than in the main phase, with values up to 50 m/s. The Sauter mean diameters of the initial and main-spray droplets were approximately 55 and 35 μm respectively and with a tendency to decrease with time from the start of injection. Received: 20 October 2000/Accepted: 30 March 2001     

Removal of Phenol Dyes Using a Photocatalytic Reactor with SnO2/Fe3O4 Nanoparticles

In this study, we present kinetics of phenol dyes removal by SnO₂/Fe₃O₄ nanoparticles in a photocatalytic reactor for optimization of this process. The effect of different concentrations of SnO₂ 5, 10, 15, 20% w/w on the photocatalytic reactor during removal of phenol red was investigated. The SnO₂/Fe₃O₄ nanoparticles were synthesized by core–shell method. The results of XRD and TEM showed the successful synthesis of these nanoparticles. Several other methods were applied to synthesis of these nanoparticles but none of them succeeded. This process composed of two-stage. The first stage was absorption by iron oxide nanoparticles and second stage was photocatalytic by tin oxide nanoparticles that followed pseudo-second-order kinetic and first-order kinetic, respectively. Optimization of this process was done corresponding to the parameters affecting the process with design expert software. In order to determine the optimal values of each of the parameters and the optimal conditions of the process, parameters were introduced to response surface methodology.     

On a Taylor-Couette Type Bifurcation for the Stationary Nonlinear Boltzmann Equation

This paper studies the stationary nonlinear Boltzmann equation for hard forces, in a Taylor-Couette setting between two coaxial, rotating cylinders with given indata of Maxwellian type on the cylinders. A priori L ^q -estimates are obtained, and used to prove a Taylor type bifurcation with isolated solutions and a hydrodynamic limit control, based on asymptotic expansions together with a rest term correction. The positivity of such solutions is also considered.     

Investigation of inclusion complex of metformin into selective cyclic peptides as novel drug delivery system: Structure,electronic properties,AIM, and NBO study via DFT

In this study, the density functional theory computational method is used to investigate the encapsulation process of metformin into three types of the cyclic peptides composed of eight serine (CP1), eight glycine (CP2), and four serine‐glycine (CP3) cyclic peptides as a new model in the process of drug delivery in the gas phase. The obtained results using the B3LYP/6‐31++G (d,p) method indicate that the complexes formed are energetically favored. Furthermore, results reveal that the drug encapsulation process is typically chemisorption. The natural bonding orbital analysis shows that the intermolecular interaction of the C2 complex (metformin/CP2) is stronger than the C1 (Metformin/CP1) and C3 (Metformin/CP3) complexes due to greater total charge transfer energy, and the C1 complex is found to be the most favored complex. The theory of atoms in molecule (AIM) method is used to analyze the nature of interactions in different molecular systems. The results show the investigated cyclic peptides as effective carriers of metformin in the nanomedicine field.